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Containing the Proceedings 47 Based upon these findings, we have proposed a theory of atypical drug oxidation in the production of agranulocytosis. It is quite possible that in the excessive digestion of these compounds some of the material may be oxidized completely and found to be benzene. The important feature of all these drugs however is that the benzene ring is the central nucleus for practically all of them. Therefore any drug that contains benzene as a central nucleus is an agent potentially capable of producing agranulocytosis in the human being. The drugs that are involved mainly in the production of agranulocytosis today include amidopyrine and all of its combinations. It is unnecessary for me to read the long list of these provided for you on the mimeographed sheets. You will notice that something like forty compounds contain amidopyrine as their essential and active ingredient and many of them are, no doubt, quite familiar to you. They include such well known preparations as allonal and amytal compound; also patented remedies as Hexin and Midol which are highly recommended by their manufacturers for suppression of menstrual pain. Pyramidon is merely another name for amidopyrine. Amidopyrine is a valuable drug and there is no question but that it gives relief from pain either alone or when combined with a large number of diflferent drugs. The resulting compounds have been given a wide variety of names, but you really still have nothing but amidopyrine. In other words, because of the remarkable efficiency of this drug, amidopyrine, in the relief of pain, the drug manufacturers have mixed it with practically everything in sight and practically every company has placed on the market one or more compounds which depend entirely on amidopyrine for their therapeutic effect. If this question involved only the use of amidopyrine it would be very simple indeed, but the difficulty is that neither the physicians nor the dentists, and certainly not the laity, are able to state which preparations do contain or do not contain amidopyrine. I feel quite sure many of you have used some of these preparations with not the slightest idea that amidopyrine was the central ingredient. That is certainly true among physicians. How are we to know what a compound contains if it is not stated by the manufacturer on the package? How is the layman to know that a preparation contains it when he walks in the drug store and the druggist tells him it will relieve a headache? Nobody but the manufacturer knows what it contains. Under the heading of patent medicines are such agents as Stanback, whose virtues are widely extolled over the radio and such as B.C., which is used widely as a remedial agent for the relief of pain. Who knows what they contain? Who knows whether or not they contain amidopyrine? Nobody but the manufacturer knows. Therefore a person who would take such compounds is nothing short of a fool. Any physician or dentist who would prescribe them for his patient is doing a grave injustice and threatening his patient with untold and perhaps extremely dire results. Since the formula is not available such preparations may contain arsenic or strychnin. There is only one rule to follow in prescribing medication. That rule is never to prescribe an agent or compound for which you do not know the formula and only then can you be safe. How many of you know the formula of Anacin? Yet you prescribe it for your patients. By doing such things how can we claim to be scientific men when led around by the detaJJ men of drug manufacturers? So far as 1 know the manufacturers of Anacin are not concerned whether or not your patients have agranulocytosis. They are mainly concerned in selling you more Anacin.
Object Description
Rating | |
Fixed Title * | NCHH-34: Bulletin of the North Carolina Dental Society [1922-1951] |
Document Title | Bulletin of the North Carolina Dental Society [1922-1951] |
Subject Topical Other | Dentistry -- North Carolina -- Periodicals.; Societies, Dental -- North Carolina -- Periodicals. |
Description | Beginning with volume 15 (Aug. 1931), August issues contain the Proceedings of the Society's Annual meeting. |
Contributor | North Carolina Dental Society. |
Publisher | Charlotte, N.C. : North Carolina Dental Society, 1922-1951. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1938-1939 |
Identifier | NCHH-34-022 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 22 |
Health Discipline | Dentistry |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-34/nchh-34-022.pdf |
Document Sort | all; group-h; nchh-34 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-34-022 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-34 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb2464819 |
Revision History | keep |
Description
Fixed Title * | Page 79 |
Document Title | Bulletin of the North Carolina Dental Society [1922-1951] |
Subject Topical Other | Dentistry -- North Carolina -- Periodicals.; Societies, Dental -- North Carolina -- Periodicals. |
Description | Beginning with volume 15 (Aug. 1931), August issues contain the Proceedings of the Society's Annual meeting. |
Contributor | North Carolina Dental Society. |
Publisher | Charlotte, N.C. : North Carolina Dental Society, 1922-1951. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1938-1939 |
Identifier | NCHH-34-022-0087 |
Form General | Periodicals |
Page Type | all; article; article title; article |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | bulletinofncdent22193839_0087.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 22 |
Issue Number | 1 |
Page Number | 79 |
Health Discipline | Dentistry |
Full Text | Containing the Proceedings 47 Based upon these findings, we have proposed a theory of atypical drug oxidation in the production of agranulocytosis. It is quite possible that in the excessive digestion of these compounds some of the material may be oxidized completely and found to be benzene. The important feature of all these drugs however is that the benzene ring is the central nucleus for practically all of them. Therefore any drug that contains benzene as a central nucleus is an agent potentially capable of producing agranulocytosis in the human being. The drugs that are involved mainly in the production of agranulocytosis today include amidopyrine and all of its combinations. It is unnecessary for me to read the long list of these provided for you on the mimeographed sheets. You will notice that something like forty compounds contain amidopyrine as their essential and active ingredient and many of them are, no doubt, quite familiar to you. They include such well known preparations as allonal and amytal compound; also patented remedies as Hexin and Midol which are highly recommended by their manufacturers for suppression of menstrual pain. Pyramidon is merely another name for amidopyrine. Amidopyrine is a valuable drug and there is no question but that it gives relief from pain either alone or when combined with a large number of diflferent drugs. The resulting compounds have been given a wide variety of names, but you really still have nothing but amidopyrine. In other words, because of the remarkable efficiency of this drug, amidopyrine, in the relief of pain, the drug manufacturers have mixed it with practically everything in sight and practically every company has placed on the market one or more compounds which depend entirely on amidopyrine for their therapeutic effect. If this question involved only the use of amidopyrine it would be very simple indeed, but the difficulty is that neither the physicians nor the dentists, and certainly not the laity, are able to state which preparations do contain or do not contain amidopyrine. I feel quite sure many of you have used some of these preparations with not the slightest idea that amidopyrine was the central ingredient. That is certainly true among physicians. How are we to know what a compound contains if it is not stated by the manufacturer on the package? How is the layman to know that a preparation contains it when he walks in the drug store and the druggist tells him it will relieve a headache? Nobody but the manufacturer knows what it contains. Under the heading of patent medicines are such agents as Stanback, whose virtues are widely extolled over the radio and such as B.C., which is used widely as a remedial agent for the relief of pain. Who knows what they contain? Who knows whether or not they contain amidopyrine? Nobody but the manufacturer knows. Therefore a person who would take such compounds is nothing short of a fool. Any physician or dentist who would prescribe them for his patient is doing a grave injustice and threatening his patient with untold and perhaps extremely dire results. Since the formula is not available such preparations may contain arsenic or strychnin. There is only one rule to follow in prescribing medication. That rule is never to prescribe an agent or compound for which you do not know the formula and only then can you be safe. How many of you know the formula of Anacin? Yet you prescribe it for your patients. By doing such things how can we claim to be scientific men when led around by the detaJJ men of drug manufacturers? So far as 1 know the manufacturers of Anacin are not concerned whether or not your patients have agranulocytosis. They are mainly concerned in selling you more Anacin. |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-34/nchh-34-022.pdf |
Document Sort | all; group-h; nchh-34 |
Article Title | The Relation of Drug Therapy to the Production of Agranulocytosis |
Article Author | Kracke, Roy R. |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-34-022 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-34 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb2464819 |
Revision History | keep |
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