Page 120 (image) |
Previous | 149 of 1043 | Next |
|
|
small (250x250 max)
medium (500x500 max)
Large
Extra Large
large ( > 500x500)
Full Resolution
|
Loading content ...
Probobly excludes deficiency Schilling test Establish etiology of malabsorption Treat with [ parenteral B12 (hydroxy-or cyanocobalamin) 1000 UGMIMQDx4-7D then Q1-2 mo. thereafter 1. Observe 2. Bone marrow 3.MMAorDST or 4. Trial of oral B12(5UGMQD) Figure 1. Evaluation of the suspected B,.-deficient patient. that time we will continue to scratch our heads, carefully observe the patient and discard the confusing 6,2 assay result. References 1 Goldberg LS, Fudenberg HH The autoimmune aspects of pernicious anemia. Am J Med 1969;46:489-94. 2. Fairbanks VF. Elveback LR. Tests for pernicious anemia: Serum vitamin B12 assay Mayo Clin Proc 1983;58:135-7. 3. McUnnan WJ. Andrews GR. Macleod C. Caird F\ Anaemia in the elderly. Q J Med 1973;165:1-13. 4. Donaldson RM "Serum BI2" and the diagnosis of cobalamin deficiency, N Engl J Med 1978;299:827-8. 5. Pierce HI. Hillman RS. The value of the serum vitamin BI2 level m diagnosing BI2 deficiency. Blood 1974;43:915-21. 6. Shojania AM. Physicians' management of suspected B12 deficiency. Can Med Assoc J 1980;123:1127-30. 7. Hutner SH, Bach MK. Ross GIM. A sugar-containing basal medium for vitamin B12-assay with Euglena; Application to body fluids J Protozool 1956;3:101-12. 8. Mollin DL. Anderson BB. Burman JF. The serum vitamin B12 level: Its assay and significance. Clin Haematol l976;5;521-46. 9. Gottlieb C. Lau K-S. Wasserman LR. Herbert V. Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B12 binding capacity, antibody to IF. and serum unsaturated B12 binding capacity. Blood 1965;25:875-84. 10. Cooper BA, Whitehead VM. Evidence thai some patients with pernicious anemia are not recognized by radiodilution assay for cobalamin in serum. N Engl J Med 1978;299:816-8. 11 Kolhouse JF, Kondo H. Allen NC. Podell E, Allen RH, Cobalamm analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin. N Engl J Med 1978;299:785-92. 12. Robertson DM. Dinsdale HB. Campbell RJ Subacute combined degeneration of the spinal cord. No association with vitamin B12 deficiency. Arch Neurol 1971;24:203-9. 13, Mclsom H. Komstad S. Abildgaard U. Reversible neuropathy of vitamin-B 12 deficiency with normal haemoglobin and serum-vitamin-B12- Lancet 1977;i:803. 14 Kubasik NP. Ricotta M. Sine HE. Commercially-supplied binders for plasma 16. cobalamin (vitamin B12), analysis-"purified"" intrinsic factor, "cobinamide"-blocked R-protein binder-compared to microbiological assay. Clin Chem 1980;26:598-600, 5. Schilling RF. Fairbanks VF. Miller R. Schmitt K. Smith MJ. "Improved" vitamin B12 assays: A report on two commercial kits. Clin Chem 1983;29; 582-3 Waters WE. Withey JL, Kilpatrick GS. Wood PHN. Abemethy M. Ten-year haematological follow-up: Mortality and haematological changes. Br Med J 1969;4;761-4. 17. Pathy MS. Kirkman S. Molloy MJ. An evaluation of simultaneously administered free and intrinsic factor bound radioactive cyanocobalamin in the diagnosis of pernicious anaemia in the elderly. J Clin Pathol 1979;32:244-50. 18. Cohen KL. Donaldson RM. Unreliability of radiodilution assays as screening tests for cobalamin (Vitamin B,,) deficiency. JAMA 1980:244:1942-5. 19. Brynskov J. Anderson K. Gimsing P. Hippe E, False low serum vitamin Bi2 values with radiodilution assays using blocked R-binders. Lancet 1983;i: 1104-5. 20. Chanarin I. The megaloblastic anaemias. 2nd ed. Oxford. England. Blackwell Scientific Publications, 1979, Doscherholmen A, Swaim WR. Impaired assimilation of egg Co57 vitamin 8,2 in patients with hypochlorhydria and achlorhydria and after gastric resection. Gastroenterology 1973;64;913-9. Fairbanks VF. Phyliky RL. Wahner HW. Results of the Schilling Test. Mayo Clin Proc 1983:58:840. 21. Fairbanks VF. Wahner HW. Valley TB. Scheidt RM. Spurious results from dual-isotope (Dicopac) vitamin B12 absorption test are due to rapid or variable rates of exchange of 58Co-B12 for 57Co-B12 bound to intrinsic factor, Nucl Med Commun 1983:4:17-23. 24. Killmann S-A. Effect of deoxyuridine on incorporation of tritiated thymidine: Difference between normoblasts and megaloblasts. Acta Med Scand 1964:175-483-8, 25. Chanarin I. England JM. Mollin C. Perry J, Methylmalonic acid excretion studies. Br J Haematol 1973:25:45-53. 26. Norman EJ. Martelo OJ. Demon MD. Cobalamin (vitamm B12) deficiency detection by urinary methylmalonic acid quantitation. Blood 1982;59: 1128-31. 27. Matchar DB, Feussner JR. Watson DJ. Millington DS. Gale D. Low serum vitamin B,j levels: Do they denote deficiency? Clin Res, 1985;33:1I-727A. 28. Savage D, Lindenbaum J. Relapses after interruption of cyanocobalamin therapy in patients with pernicious anemia. Am J Med 1983;74:765-72. 21 22 120 Vol. 47, No. 2
Object Description
Rating | |
Fixed Title * | NCHH-17: North Carolina Medical Journal [1940-Present] |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1986 |
Identifier | NCHH-17-047 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 47 |
Health Discipline | Medicine |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-047.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-047 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Description
Fixed Title * | Page 120 (image) |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1986 |
Identifier | NCHH-17-047-0154 |
Form General | Periodicals |
Page Type | all; all images; diagram; article |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | ncmed471986medi1_0154.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 47 |
Issue Number | 3 |
Page Number | 120 |
Health Discipline | Medicine |
Full Text | Probobly excludes deficiency Schilling test Establish etiology of malabsorption Treat with [ parenteral B12 (hydroxy-or cyanocobalamin) 1000 UGMIMQDx4-7D then Q1-2 mo. thereafter 1. Observe 2. Bone marrow 3.MMAorDST or 4. Trial of oral B12(5UGMQD) Figure 1. Evaluation of the suspected B,.-deficient patient. that time we will continue to scratch our heads, carefully observe the patient and discard the confusing 6,2 assay result. References 1 Goldberg LS, Fudenberg HH The autoimmune aspects of pernicious anemia. Am J Med 1969;46:489-94. 2. Fairbanks VF. Elveback LR. Tests for pernicious anemia: Serum vitamin B12 assay Mayo Clin Proc 1983;58:135-7. 3. McUnnan WJ. Andrews GR. Macleod C. Caird F\ Anaemia in the elderly. Q J Med 1973;165:1-13. 4. Donaldson RM "Serum BI2" and the diagnosis of cobalamin deficiency, N Engl J Med 1978;299:827-8. 5. Pierce HI. Hillman RS. The value of the serum vitamin BI2 level m diagnosing BI2 deficiency. Blood 1974;43:915-21. 6. Shojania AM. Physicians' management of suspected B12 deficiency. Can Med Assoc J 1980;123:1127-30. 7. Hutner SH, Bach MK. Ross GIM. A sugar-containing basal medium for vitamin B12-assay with Euglena; Application to body fluids J Protozool 1956;3:101-12. 8. Mollin DL. Anderson BB. Burman JF. The serum vitamin B12 level: Its assay and significance. Clin Haematol l976;5;521-46. 9. Gottlieb C. Lau K-S. Wasserman LR. Herbert V. Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B12 binding capacity, antibody to IF. and serum unsaturated B12 binding capacity. Blood 1965;25:875-84. 10. Cooper BA, Whitehead VM. Evidence thai some patients with pernicious anemia are not recognized by radiodilution assay for cobalamin in serum. N Engl J Med 1978;299:816-8. 11 Kolhouse JF, Kondo H. Allen NC. Podell E, Allen RH, Cobalamm analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin. N Engl J Med 1978;299:785-92. 12. Robertson DM. Dinsdale HB. Campbell RJ Subacute combined degeneration of the spinal cord. No association with vitamin B12 deficiency. Arch Neurol 1971;24:203-9. 13, Mclsom H. Komstad S. Abildgaard U. Reversible neuropathy of vitamin-B 12 deficiency with normal haemoglobin and serum-vitamin-B12- Lancet 1977;i:803. 14 Kubasik NP. Ricotta M. Sine HE. Commercially-supplied binders for plasma 16. cobalamin (vitamin B12), analysis-"purified"" intrinsic factor, "cobinamide"-blocked R-protein binder-compared to microbiological assay. Clin Chem 1980;26:598-600, 5. Schilling RF. Fairbanks VF. Miller R. Schmitt K. Smith MJ. "Improved" vitamin B12 assays: A report on two commercial kits. Clin Chem 1983;29; 582-3 Waters WE. Withey JL, Kilpatrick GS. Wood PHN. Abemethy M. Ten-year haematological follow-up: Mortality and haematological changes. Br Med J 1969;4;761-4. 17. Pathy MS. Kirkman S. Molloy MJ. An evaluation of simultaneously administered free and intrinsic factor bound radioactive cyanocobalamin in the diagnosis of pernicious anaemia in the elderly. J Clin Pathol 1979;32:244-50. 18. Cohen KL. Donaldson RM. Unreliability of radiodilution assays as screening tests for cobalamin (Vitamin B,,) deficiency. JAMA 1980:244:1942-5. 19. Brynskov J. Anderson K. Gimsing P. Hippe E, False low serum vitamin Bi2 values with radiodilution assays using blocked R-binders. Lancet 1983;i: 1104-5. 20. Chanarin I. The megaloblastic anaemias. 2nd ed. Oxford. England. Blackwell Scientific Publications, 1979, Doscherholmen A, Swaim WR. Impaired assimilation of egg Co57 vitamin 8,2 in patients with hypochlorhydria and achlorhydria and after gastric resection. Gastroenterology 1973;64;913-9. Fairbanks VF. Phyliky RL. Wahner HW. Results of the Schilling Test. Mayo Clin Proc 1983:58:840. 21. Fairbanks VF. Wahner HW. Valley TB. Scheidt RM. Spurious results from dual-isotope (Dicopac) vitamin B12 absorption test are due to rapid or variable rates of exchange of 58Co-B12 for 57Co-B12 bound to intrinsic factor, Nucl Med Commun 1983:4:17-23. 24. Killmann S-A. Effect of deoxyuridine on incorporation of tritiated thymidine: Difference between normoblasts and megaloblasts. Acta Med Scand 1964:175-483-8, 25. Chanarin I. England JM. Mollin C. Perry J, Methylmalonic acid excretion studies. Br J Haematol 1973:25:45-53. 26. Norman EJ. Martelo OJ. Demon MD. Cobalamin (vitamm B12) deficiency detection by urinary methylmalonic acid quantitation. Blood 1982;59: 1128-31. 27. Matchar DB, Feussner JR. Watson DJ. Millington DS. Gale D. Low serum vitamin B,j levels: Do they denote deficiency? Clin Res, 1985;33:1I-727A. 28. Savage D, Lindenbaum J. Relapses after interruption of cyanocobalamin therapy in patients with pernicious anemia. Am J Med 1983;74:765-72. 21 22 120 Vol. 47, No. 2 |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-047.pdf |
Document Sort | all; nchh-17 |
Article Title | Laboratory Tests In The Diagnosis Of Vitamin B12 (Cobalannin) Deficiency |
Article Author | David B. Matchar; And John R. Feussner |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-047 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Tags
Comments
Post a Comment for Page 120 (image)