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84 BrLLETIN N. C. BOARD OF HEALTH. Stanly, Rowan, Alleghany, Richmond, Harnett and Warren. This list by no moans includes all the counties where the disease has been recognized, but is sufficient to demonstrate our contention that it is generally distributed. If any one section of the State is suffering more than another it is the south central counties. The largest number of cases have naturally been reported from Wilmington, Charlotte, Greensboro, Durham and Asheville, which may possibly be explained on the ground that these cities are medical centers of their respective sections. There are definite records of probably 200 cases in North Carolina. It is difficult to estimate how many cases occur in the State as a whole. It is certain that only a small portion have been recognized. It should be remembered in this connection that pellagra may occur in children in such a mild form as never to attract sufficient attention to call for the services of a physician. It is no unusual thing for us to find, in running down one case, four or five more very mild cases in the same house. Etiology.—Since this disease was first recognized maize has been connected with its etiology. The Italians have claimed for years that pellagra was due to eating maize, but have disagreed among themselves as to what bacteria or fungi acting upon the maize produce the toxin, if a toxin of exogenous origin is the cause, or what bacteria using maize as a culture medium are carried into the body with it. Lombroso claimed that the maize became decomposed and a toxin, called by him pellagrozein, was produced which caused the disease. Other observers claim that fungi of the genus Aspergillus was the causative agent. We have just received an ear of corn upon which the fungus TJstll-ago is growing, producing a black smut called dustbrand and causing each grain of corn to appear like a large blue tick, which, upon being opened, shows the black smut. This is being grown and examined with regard to its being a possible cause. Tizzoni of Italy has isolated from pellagrins a streptobacillus which is polymorphous, does not form spores and resists for an hour a temperature of 90° C. He has inoculated guinea pigs with it and produced death in 30 to 80 days, which was preceded by emaciation, diarrhea and falling of hair. He has also found the same organism in maize and has produced the same symptoms with it in the guinea pig as those produced by the one from pellagrins. To produce the disease per as, he has to mix the organism with corn meal, as the organism is not pathogenic when fed by itself. Injected beneath the skin the organism is pathogenic. The French claim that poverty, with its resulting poor hygiene and poorer food, is the cause. This might be predisposing, but not causative, as this disease is seen in people of the better walks of life. They recognize a pseudo-pellagra and a true pellagra.
Object Description
Rating | |
Fixed Title * | NCHH-03: Bulletin of the North Carolina Board of Health [1886-1913] |
Document Title | Bulletin of the North Carolina Board of Health [1886-1913] |
Subject Topical | Public health -- North Carolina -- Periodicals. |
Subject Topical Other | Public Health -- North Carolina -- Periodicals. |
Description | Published: 1886-1913. |
Contributor | North Carolina. State Board of Health. |
Publisher | Wilmington, N.C. : Secretary of the Board, 1886-1913. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1909-1910 |
Identifier | NCHH-03-024 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 24 |
Health Discipline | Public Health |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-03/nchh-03-024.pdf |
Document Sort | all; group-b; nchh-03 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-03-024 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-03 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1324480 |
Description
Fixed Title * | Page 84 |
Document Title | Bulletin of the North Carolina Board of Health [1886-1913] |
Subject Topical | Public health -- North Carolina -- Periodicals. |
Subject Topical Other | Public Health -- North Carolina -- Periodicals. |
Description | Published: 1886-1913. |
Contributor | North Carolina. State Board of Health. |
Publisher | Wilmington, N.C. : Secretary of the Board, 1886-1913. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1909-1910 |
Identifier | NCHH-03-024-0092 |
Form General | Periodicals |
Page Type | all; article |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | bulletinofnorthc24nort_0092.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 24 |
Issue Number | 7 |
Page Number | 84 |
Health Discipline | Public Health |
Full Text | 84 BrLLETIN N. C. BOARD OF HEALTH. Stanly, Rowan, Alleghany, Richmond, Harnett and Warren. This list by no moans includes all the counties where the disease has been recognized, but is sufficient to demonstrate our contention that it is generally distributed. If any one section of the State is suffering more than another it is the south central counties. The largest number of cases have naturally been reported from Wilmington, Charlotte, Greensboro, Durham and Asheville, which may possibly be explained on the ground that these cities are medical centers of their respective sections. There are definite records of probably 200 cases in North Carolina. It is difficult to estimate how many cases occur in the State as a whole. It is certain that only a small portion have been recognized. It should be remembered in this connection that pellagra may occur in children in such a mild form as never to attract sufficient attention to call for the services of a physician. It is no unusual thing for us to find, in running down one case, four or five more very mild cases in the same house. Etiology.—Since this disease was first recognized maize has been connected with its etiology. The Italians have claimed for years that pellagra was due to eating maize, but have disagreed among themselves as to what bacteria or fungi acting upon the maize produce the toxin, if a toxin of exogenous origin is the cause, or what bacteria using maize as a culture medium are carried into the body with it. Lombroso claimed that the maize became decomposed and a toxin, called by him pellagrozein, was produced which caused the disease. Other observers claim that fungi of the genus Aspergillus was the causative agent. We have just received an ear of corn upon which the fungus TJstll-ago is growing, producing a black smut called dustbrand and causing each grain of corn to appear like a large blue tick, which, upon being opened, shows the black smut. This is being grown and examined with regard to its being a possible cause. Tizzoni of Italy has isolated from pellagrins a streptobacillus which is polymorphous, does not form spores and resists for an hour a temperature of 90° C. He has inoculated guinea pigs with it and produced death in 30 to 80 days, which was preceded by emaciation, diarrhea and falling of hair. He has also found the same organism in maize and has produced the same symptoms with it in the guinea pig as those produced by the one from pellagrins. To produce the disease per as, he has to mix the organism with corn meal, as the organism is not pathogenic when fed by itself. Injected beneath the skin the organism is pathogenic. The French claim that poverty, with its resulting poor hygiene and poorer food, is the cause. This might be predisposing, but not causative, as this disease is seen in people of the better walks of life. They recognize a pseudo-pellagra and a true pellagra. |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-03/nchh-03-024.pdf |
Document Sort | all; group-b; nchh-03 |
Article Title | Pellagra |
Article Author | Wood, Edward J. |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-03-024 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-03 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1324480 |
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