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86 BULLETIN jN". C. BOARD OF HEALTH. toxin being eliminated by the intestinal tract and that in the process of elimination a varying amount of irritation is produced. It is claimed that this same elimination process accounts for the stomatitis. Abnormal pigmentation seems to be rather peculiar to pellagra. It can hardly be distinguished from senile pigmentation. It occurs especially in the ganglion cells, the heart muscle (brown atrophy), the liver cells and the spleen. The most important change brought about by pellagra is in the nervous system. It should not be lost sight of that the variously described conditions of hyper?emia, anjemia, oedema and obliteration of the central canal of the spinal cord are common to many chronic nervous diseases. The posterior and the lateral columns of the cord are afCected in pellagra. In our own series of cases 38 per cent had exaggerated pateller reflexes indicating affection of the lateral columns, 25 per cent had symptoms of affection of the posterior columns, while 44 per cent remained normal. It is usually considered that the weight of the disease falls on the crossed pyramidal tract. The direct cerebellar ti'act and the posterior root zones are never affected. The lesions of the posterior columns fall chiefly on the cervical and upper dorsal regions, while those of the lateral columns affect chiefly the middle and lower third of the dorsal region. There is often a very rich pigmentation of the nerve cells of the cord, and also of the spinal and sympathetic ganglia. This has been erroneously termed pigment atrophy. The assertion of Dejerine that there is degeneration of the peripheral nerves in pellagra should be accepted with some reserve; such changes are apt to occur in many diseases. Mariani's view, that arteriosclerosis is a concomitant of pellagra, seems to be erroneous. Lukacs and Fabinyi found the arteries remarkably sound. The central canal of the cord, as above mentioned, is frequently obliterated, while in other cases it is twisted and displaced. The glia of the commissure may be much increased. In the cerebrum the layer of small pyramidal cells is unaffected, likewise the layer of large pyramidal cells, while in the deeper layers the nerve cells are markedly affected. The layer of polygonal and spindle cells is for the most part unchanged. In the most severely damaged cells the body is swollen, homogeneously granular, monochromatic, and at most a little darkened at the edges. It is generally acknowledged that degeneration of the motor ganglion cells is more marked than that of the sensory. In the cord the cells of the anterior cornua are especially affected, and while the cells of the posterior cornua also are affected, the disease is here not near so marked.
Object Description
Rating | |
Fixed Title * | NCHH-03: Bulletin of the North Carolina Board of Health [1886-1913] |
Document Title | Bulletin of the North Carolina Board of Health [1886-1913] |
Subject Topical | Public health -- North Carolina -- Periodicals. |
Subject Topical Other | Public Health -- North Carolina -- Periodicals. |
Description | Published: 1886-1913. |
Contributor | North Carolina. State Board of Health. |
Publisher | Wilmington, N.C. : Secretary of the Board, 1886-1913. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1909-1910 |
Identifier | NCHH-03-024 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 24 |
Health Discipline | Public Health |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-03/nchh-03-024.pdf |
Document Sort | all; group-b; nchh-03 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-03-024 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-03 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1324480 |
Description
Fixed Title * | Page 86 |
Document Title | Bulletin of the North Carolina Board of Health [1886-1913] |
Subject Topical | Public health -- North Carolina -- Periodicals. |
Subject Topical Other | Public Health -- North Carolina -- Periodicals. |
Description | Published: 1886-1913. |
Contributor | North Carolina. State Board of Health. |
Publisher | Wilmington, N.C. : Secretary of the Board, 1886-1913. |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1909-1910 |
Identifier | NCHH-03-024-0094 |
Form General | Periodicals |
Page Type | all; article |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | bulletinofnorthc24nort_0094.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 24 |
Issue Number | 7 |
Page Number | 86 |
Health Discipline | Public Health |
Full Text | 86 BULLETIN jN". C. BOARD OF HEALTH. toxin being eliminated by the intestinal tract and that in the process of elimination a varying amount of irritation is produced. It is claimed that this same elimination process accounts for the stomatitis. Abnormal pigmentation seems to be rather peculiar to pellagra. It can hardly be distinguished from senile pigmentation. It occurs especially in the ganglion cells, the heart muscle (brown atrophy), the liver cells and the spleen. The most important change brought about by pellagra is in the nervous system. It should not be lost sight of that the variously described conditions of hyper?emia, anjemia, oedema and obliteration of the central canal of the spinal cord are common to many chronic nervous diseases. The posterior and the lateral columns of the cord are afCected in pellagra. In our own series of cases 38 per cent had exaggerated pateller reflexes indicating affection of the lateral columns, 25 per cent had symptoms of affection of the posterior columns, while 44 per cent remained normal. It is usually considered that the weight of the disease falls on the crossed pyramidal tract. The direct cerebellar ti'act and the posterior root zones are never affected. The lesions of the posterior columns fall chiefly on the cervical and upper dorsal regions, while those of the lateral columns affect chiefly the middle and lower third of the dorsal region. There is often a very rich pigmentation of the nerve cells of the cord, and also of the spinal and sympathetic ganglia. This has been erroneously termed pigment atrophy. The assertion of Dejerine that there is degeneration of the peripheral nerves in pellagra should be accepted with some reserve; such changes are apt to occur in many diseases. Mariani's view, that arteriosclerosis is a concomitant of pellagra, seems to be erroneous. Lukacs and Fabinyi found the arteries remarkably sound. The central canal of the cord, as above mentioned, is frequently obliterated, while in other cases it is twisted and displaced. The glia of the commissure may be much increased. In the cerebrum the layer of small pyramidal cells is unaffected, likewise the layer of large pyramidal cells, while in the deeper layers the nerve cells are markedly affected. The layer of polygonal and spindle cells is for the most part unchanged. In the most severely damaged cells the body is swollen, homogeneously granular, monochromatic, and at most a little darkened at the edges. It is generally acknowledged that degeneration of the motor ganglion cells is more marked than that of the sensory. In the cord the cells of the anterior cornua are especially affected, and while the cells of the posterior cornua also are affected, the disease is here not near so marked. |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-03/nchh-03-024.pdf |
Document Sort | all; group-b; nchh-03 |
Article Title | Pellagra |
Article Author | Wood, Edward J. |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-03-024 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-03 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1324480 |
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