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Where th< s smoke...there may be bronchitis "Recent research has delineated early, more subtle changes in lung and immune functions. These alterations directly predispose smokers to respiratory tract infection." Am Fam Phys 1987;36:133-140 cefaclor Pulvuies * 250 rrrg Established therapy for today's patients For respiratory tract infections due to susceptible strains of indicated organisms Brief Summary. Consult the package literature for prescribing information. Indication: Lower respiratory infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes (group A ^-hemolytic streptococci). Contraindication: Known allergy to cephalosporins. WarntoQs: CECLOR SHOULD BE ADMINISTERED CAUTIOUSLY TO PENICILLIN-SENSITIVE PATIENTS. PENICILLINS AND CEPHALOSPORINS SHOW PARTIAL CROSS-ALLERGENICITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cautiously to allergic patients. Pseudomembranous colitis has been reported with virtually all broad-spectrum antibiotics. It must be considered in differential diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antibiotic treatment possibly resulting in antibiotic-associated colitis. Precautions: � Discontinue Ceclor in the event of allergic reactions to it. � Prolonged use may result in overgrowth of non-susceptible organisms. � Positive direct Coombs' tests have been reported {hiring treatment with cephaJosporins. � Ceclor should be administered with caution in the presence of markedly -ipaired renal function. Although dosage adjustments if! moderate to severe renal UTrpairment are usually not required, careful clinical observation and laboratory studies should be made. � Broad-spectrum antibiotics should be prescribed with caution in indmduals with a history of gastrointestinal disease, particularly colitis. � Safety and effectiveness have not been determined in pregnancy, lactation, and infants less than one month old. Ceclor penetrates mother's milk. Exercise caution in prescribing for these patients. Adverse Reactions: (percentage of patients) Therapy-related adverse reactions are uncommon. Those reported include: � Hypersensitivity reactions have been reported in about 1.5% of patients and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur in less than 1 in 200 patients. Cases of serum-sickness-lrke reactions have been reported with the use of Ceclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied by armritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently associated lyrnphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction. While further investigation is ongoing, serum-sickness-Hke reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with Ceclor. Such reactions have been reported more frequently in children than in adults with an overall occurrence ranging from 1 in 200 (0.5%) in one focused trial to 2 in 8.346 (0.024%) in overall clinical trials (with an incidence in children in clinical trials of 0.055%) to 1 in 38,000 (0.0133%) in spontaneous event reports. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy; occasionally these reactions have resulted in hospitalization, usually of short duration (median hospitalization = two to three days, based on postmarketing surveillance studies). In those requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in children. Antihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been reported. � Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patients with a history of penicillin allergy. � Gastrointestinal (mostly diarrhea): 2.5% � Symptoms of pseudomembranous colitis may appear either during or after amibiotic treatment. � As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. � Rarely, reversible hyperactivity, nervousness, msomnia, confusion, hypertonia, dizziness, and somnolence have been reported. � Other: eosinophilia, 2%; genital pruritus or vaginitis, less than 1% and, rarely, thrornrjocytopenia and reversible interstitial nephritis. Abnormalities in laboratory results of uncertain etiology. � Slight elevations in hepatic enzymes. � Transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia and reversible neutropenia. � Rare reports of increased prothrombin time with or without clinical bleeding in patients receiving Ceclor and Coumadin concomitantly. � Abnormal urinalysis; elevations in BUN or serum creatinine. � Positive direct Coombs' test. � False-positive tests for urinary glucose with Benedict's or Fehling's solution and Clinitest- tablets but not with Tes-Tape* (glucose enzymatic test strip, Lilly). PA 8791 AMP [021430LR1] Additional information available to the profession on request from Eli Lilly and Company, Indianapolis, Indiana 46285. Eli Lilly Industries, Inc Carolina, Puerto Rico 00630 A Subsidiary of Eli Lilly and Company Indianapolis, Indiana 46285 CR-O525-B-049333 � 1990, EU LILLY AND COMPANY
Object Description
Rating | |
Fixed Title * | NCHH-17: North Carolina Medical Journal [1940-Present] |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1991 |
Identifier | NCHH-17-052 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 52 |
Health Discipline | Medicine |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-052.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-052 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Description
Fixed Title * | Page 32 (advert) |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1991 |
Identifier | NCHH-17-052-0036 |
Form General | Periodicals |
Page Type | all; all images; advertisement |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | ncmed521991medi_0036.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 52 |
Issue Number | 1 |
Page Number | 32 |
Health Discipline | Medicine |
Full Text | Where th< s smoke...there may be bronchitis "Recent research has delineated early, more subtle changes in lung and immune functions. These alterations directly predispose smokers to respiratory tract infection." Am Fam Phys 1987;36:133-140 cefaclor Pulvuies * 250 rrrg Established therapy for today's patients For respiratory tract infections due to susceptible strains of indicated organisms Brief Summary. Consult the package literature for prescribing information. Indication: Lower respiratory infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes (group A ^-hemolytic streptococci). Contraindication: Known allergy to cephalosporins. WarntoQs: CECLOR SHOULD BE ADMINISTERED CAUTIOUSLY TO PENICILLIN-SENSITIVE PATIENTS. PENICILLINS AND CEPHALOSPORINS SHOW PARTIAL CROSS-ALLERGENICITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cautiously to allergic patients. Pseudomembranous colitis has been reported with virtually all broad-spectrum antibiotics. It must be considered in differential diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antibiotic treatment possibly resulting in antibiotic-associated colitis. Precautions: � Discontinue Ceclor in the event of allergic reactions to it. � Prolonged use may result in overgrowth of non-susceptible organisms. � Positive direct Coombs' tests have been reported {hiring treatment with cephaJosporins. � Ceclor should be administered with caution in the presence of markedly -ipaired renal function. Although dosage adjustments if! moderate to severe renal UTrpairment are usually not required, careful clinical observation and laboratory studies should be made. � Broad-spectrum antibiotics should be prescribed with caution in indmduals with a history of gastrointestinal disease, particularly colitis. � Safety and effectiveness have not been determined in pregnancy, lactation, and infants less than one month old. Ceclor penetrates mother's milk. Exercise caution in prescribing for these patients. Adverse Reactions: (percentage of patients) Therapy-related adverse reactions are uncommon. Those reported include: � Hypersensitivity reactions have been reported in about 1.5% of patients and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur in less than 1 in 200 patients. Cases of serum-sickness-lrke reactions have been reported with the use of Ceclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied by armritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently associated lyrnphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction. While further investigation is ongoing, serum-sickness-Hke reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with Ceclor. Such reactions have been reported more frequently in children than in adults with an overall occurrence ranging from 1 in 200 (0.5%) in one focused trial to 2 in 8.346 (0.024%) in overall clinical trials (with an incidence in children in clinical trials of 0.055%) to 1 in 38,000 (0.0133%) in spontaneous event reports. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy; occasionally these reactions have resulted in hospitalization, usually of short duration (median hospitalization = two to three days, based on postmarketing surveillance studies). In those requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in children. Antihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been reported. � Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patients with a history of penicillin allergy. � Gastrointestinal (mostly diarrhea): 2.5% � Symptoms of pseudomembranous colitis may appear either during or after amibiotic treatment. � As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. � Rarely, reversible hyperactivity, nervousness, msomnia, confusion, hypertonia, dizziness, and somnolence have been reported. � Other: eosinophilia, 2%; genital pruritus or vaginitis, less than 1% and, rarely, thrornrjocytopenia and reversible interstitial nephritis. Abnormalities in laboratory results of uncertain etiology. � Slight elevations in hepatic enzymes. � Transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia and reversible neutropenia. � Rare reports of increased prothrombin time with or without clinical bleeding in patients receiving Ceclor and Coumadin concomitantly. � Abnormal urinalysis; elevations in BUN or serum creatinine. � Positive direct Coombs' test. � False-positive tests for urinary glucose with Benedict's or Fehling's solution and Clinitest- tablets but not with Tes-Tape* (glucose enzymatic test strip, Lilly). PA 8791 AMP [021430LR1] Additional information available to the profession on request from Eli Lilly and Company, Indianapolis, Indiana 46285. Eli Lilly Industries, Inc Carolina, Puerto Rico 00630 A Subsidiary of Eli Lilly and Company Indianapolis, Indiana 46285 CR-O525-B-049333 � 1990, EU LILLY AND COMPANY |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-052.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-052 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
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