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"Recent research has delineated early, more subtle changes in lung and immune functions. These alterations directly predispose smokers to respiratory tract infection" Am Fam Phys 1987;36:133-140 Pulvutes' 250 mg Established therapy far today's patients For respiratory tract infections due to susceptible strains of Indicated organisms Bmi Som^ary. Coosdt ttte padcase (ftemsre for ^Bscrlr^ ^ormatioii Ifttllcatton: Lower respiratory infections, including pneumonia, caused by Streptococcus pneumoniae, H8efnQ0ifus inflmz^, and StreiAococcus pyogenes (group A ^-hemoiytic stfeptococoij. DmtFstoil^^at^: Known ailergy to cephalosporins. WaratRQs: CECLOR SHOULD BE ADMfNlSTERED CAUTiOUSi:^ TO PENICtLLtN-SENSmVE PATIENTS. PENiCILUNS AND CEPHALOSPORINS SHOW PARTIAL CflOSS-ALLERGENIOITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cauttousJy to altefgic patients. PseiKtomentoanous colitis has been reported with vtftuaHy all broad-spectrum antibiotics, ft must be considered m differentia} diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antMwsic treatment, possibly resulting in andbiotic-associated cotltis. FrBcaiitNm: • Dtscctfrtinue Cecto in the event of ailer^ reactions to It. • Proionged use may result in overgrowth of non-susceptlbie organisms. • Positive direct Coombs' tests have been reported during treatment with ce^alosporins. • Ceclor should be administered with caution in the presence of markedly impaired renal function. Although dosage adjustments in moderate to severe renal impairment are usually not required, careful clinical observation and laboratory studies shouki be made. • Broad-^j^trum anibiotics shoutd be prescribed vnth caution in mdivtduals with a history of gastrointestinal disease, particularly coJItis. • Safety and effectiveness have mS been determined in pregnan(^, lactation, and infants less than one month old. Ceclor penetrates mother's milk. Exercise caution In prescribing for these patients. Adverse Reacts: (percentage o! patients) Therapy-related adverse reactions are uncommon. Those reported include: • Hypersensitivity reactions have been reported in about 1.5% of padents and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur In less than 1 in 200 patients. Cases of sefBB-sickftess-like reactions have been reported with the use of Ceclor. These are characterized by findirigs of erythema multiforme, rashes, and other skin manifestations accom^ied by arthritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently assojiated lymphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction. \^ile further investigation is ongoing, serra^Ksess-like reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of fterapy with Ceclor. Such reacttons have been reported more frequently in children than m adults with an overall occurT©K« ranging from 1 in 200 (0.5%) in one focused trial to 2 in 8.346 (0.024%) in overall clinical trials (with an incidence in children in clinical trials of 0.055%) to 1 in 38m (0.(X)3%) in spontaneous evCTt reports. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy; occasionally these reactions have resulted in h^italization. usually of short duration (median hospitalizatiwi = two to three days, based on postmarketing surveillance studies). In those requiring hospitalization, the syn^ toms have ranged from miW to severe at the time of admission with more of the severe reactions occurring in chikJren. Amihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been rep^ed. • Stevens-Johnson syndrome, toxic epidermal necrolysis. and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patterns with a history of penicillin allergy. • Gastrointestinal (mostly diarrtiea): 2.5% • Symptoms of pseudomembranous colids may appear either during or after antibiotic treatment. • As with some penicillins and some other cephalosporins. transient hepatitis and cholestatic jaundice have been reported rarely. • Rarely, reversible hyperactivity, nervousness, insomnia, confusion, hypertonia, dizziness, and somnolence have been reported. • Other: eosinophilia, 2%; genital pruritus or va^nids, less than 1% and, rar^, thrombocytop^a aid reversible Interstitiai nephritis. Abnormalities in la^tory results of uncertain etiology. • Slight elevadons in hepauc enzymes. • Transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia and reversible neutrop^, • Rare reports of increased prothrombin time with or without clinical bleeding in patiente rec^ng Ceclor and Coumadin concomitamiy. • Abnormal urinalysis; elevations in BUN or serum creatmine. • Positive direct Coombs' test. • False-positive tests for urinary glucose with Benedict's or Fehling's solution and Ctinitest^ tablets but not wt^ Tes-Tape* (glucose enzymatic test strip. Lilly). PA 8791 AMP [02148GLRIj Additional information available to the profession on r&jmt frm EH Ully and Company. Indianapolis, Indiana 46285. Qi Lffiy industries, (nc Carc^ina, Puerto Rico {XI630 A Subsidiary of Bl Lilly and Company Indianapolis. Indiana 46285 CR-0525-B-049333 ©1990, £U UaY AfK) COMPANY
Object Description
Rating | |
Fixed Title * | NCHH-17: North Carolina Medical Journal [1940-Present] |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1990 |
Identifier | NCHH-17-051 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 51 |
Health Discipline | Medicine |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-051.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-051 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Description
Fixed Title * | Page 525 (advert) |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1990 |
Identifier | NCHH-17-051-0897 |
Form General | Periodicals |
Page Type | all; all images; advertisement |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | ncmed511990medi_0897.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 51 |
Issue Number | 10 |
Page Number | 525 |
Health Discipline | Medicine |
Full Text | "Recent research has delineated early, more subtle changes in lung and immune functions. These alterations directly predispose smokers to respiratory tract infection" Am Fam Phys 1987;36:133-140 Pulvutes' 250 mg Established therapy far today's patients For respiratory tract infections due to susceptible strains of Indicated organisms Bmi Som^ary. Coosdt ttte padcase (ftemsre for ^Bscrlr^ ^ormatioii Ifttllcatton: Lower respiratory infections, including pneumonia, caused by Streptococcus pneumoniae, H8efnQ0ifus inflmz^, and StreiAococcus pyogenes (group A ^-hemoiytic stfeptococoij. DmtFstoil^^at^: Known ailergy to cephalosporins. WaratRQs: CECLOR SHOULD BE ADMfNlSTERED CAUTiOUSi:^ TO PENICtLLtN-SENSmVE PATIENTS. PENiCILUNS AND CEPHALOSPORINS SHOW PARTIAL CflOSS-ALLERGENIOITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cauttousJy to altefgic patients. PseiKtomentoanous colitis has been reported with vtftuaHy all broad-spectrum antibiotics, ft must be considered m differentia} diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antMwsic treatment, possibly resulting in andbiotic-associated cotltis. FrBcaiitNm: • Dtscctfrtinue Cecto in the event of ailer^ reactions to It. • Proionged use may result in overgrowth of non-susceptlbie organisms. • Positive direct Coombs' tests have been reported during treatment with ce^alosporins. • Ceclor should be administered with caution in the presence of markedly impaired renal function. Although dosage adjustments in moderate to severe renal impairment are usually not required, careful clinical observation and laboratory studies shouki be made. • Broad-^j^trum anibiotics shoutd be prescribed vnth caution in mdivtduals with a history of gastrointestinal disease, particularly coJItis. • Safety and effectiveness have mS been determined in pregnan(^, lactation, and infants less than one month old. Ceclor penetrates mother's milk. Exercise caution In prescribing for these patients. Adverse Reacts: (percentage o! patients) Therapy-related adverse reactions are uncommon. Those reported include: • Hypersensitivity reactions have been reported in about 1.5% of padents and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur In less than 1 in 200 patients. Cases of sefBB-sickftess-like reactions have been reported with the use of Ceclor. These are characterized by findirigs of erythema multiforme, rashes, and other skin manifestations accom^ied by arthritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently assojiated lymphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction. \^ile further investigation is ongoing, serra^Ksess-like reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of fterapy with Ceclor. Such reacttons have been reported more frequently in children than m adults with an overall occurT©K« ranging from 1 in 200 (0.5%) in one focused trial to 2 in 8.346 (0.024%) in overall clinical trials (with an incidence in children in clinical trials of 0.055%) to 1 in 38m (0.(X)3%) in spontaneous evCTt reports. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy; occasionally these reactions have resulted in h^italization. usually of short duration (median hospitalizatiwi = two to three days, based on postmarketing surveillance studies). In those requiring hospitalization, the syn^ toms have ranged from miW to severe at the time of admission with more of the severe reactions occurring in chikJren. Amihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been rep^ed. • Stevens-Johnson syndrome, toxic epidermal necrolysis. and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patterns with a history of penicillin allergy. • Gastrointestinal (mostly diarrtiea): 2.5% • Symptoms of pseudomembranous colids may appear either during or after antibiotic treatment. • As with some penicillins and some other cephalosporins. transient hepatitis and cholestatic jaundice have been reported rarely. • Rarely, reversible hyperactivity, nervousness, insomnia, confusion, hypertonia, dizziness, and somnolence have been reported. • Other: eosinophilia, 2%; genital pruritus or va^nids, less than 1% and, rar^, thrombocytop^a aid reversible Interstitiai nephritis. Abnormalities in la^tory results of uncertain etiology. • Slight elevadons in hepauc enzymes. • Transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia and reversible neutrop^, • Rare reports of increased prothrombin time with or without clinical bleeding in patiente rec^ng Ceclor and Coumadin concomitamiy. • Abnormal urinalysis; elevations in BUN or serum creatmine. • Positive direct Coombs' test. • False-positive tests for urinary glucose with Benedict's or Fehling's solution and Ctinitest^ tablets but not wt^ Tes-Tape* (glucose enzymatic test strip. Lilly). PA 8791 AMP [02148GLRIj Additional information available to the profession on r&jmt frm EH Ully and Company. Indianapolis, Indiana 46285. Qi Lffiy industries, (nc Carc^ina, Puerto Rico {XI630 A Subsidiary of Bl Lilly and Company Indianapolis. Indiana 46285 CR-0525-B-049333 ©1990, £U UaY AfK) COMPANY |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-051.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-051 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
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