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^ imoke-.there may be bronchitis "Recent research has delineated early, more subtle changes in lung and -Immune functions. These alterations directly predispose smokers to respiratory tract infection." Am fam Phys 1987;36:133-140 Established therapy for today's patients For respiratory tract Infections due to susceptible strains of Indicated organisms Brfef Sufflmary. Consult tl» package IftBratore for prescffiitag WormatkM. IfidlGatlon: Lower respifatory infectiofls. Including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes (group A 3-tiemolytlc streptococci). Ccmtralmticathffl: Known allergy to cephalosporins. Warnings: CECLOR SHOULD BE ADMINISTERED CAUTIOUSLY TO PENICILLIN-SENSITIVE PATIENTS. PENICILLINS AND CEPHALOSPORINS SHCRS PARTIAL CROSS-ALLEfiGENICITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cautiously to altefgic patients. Pseudomemtjranous colitis has been reported with virtually all tjroad-spectrum antibiotics. It must be considered in differential diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antibiotic treatment, possibly resulting in antibiotic-associated colitis. Pracautions; • Discontinue Ceclor In the event of aliergN: reactions to it. • Prolonged use may result in overgrowth of non-susceptible organisms. • Positive direct Coombs' tests have been reported during treatment with cephalosporins. • Oeclor should be administered with caution in ttie presence of markedly impaired renal hjnction. Although dosage adjustments in moderate to severe renal Impairment are usually not required, careful clinical ob^rvatlon and laboratory studies should be made. • Sroad-spBGtrum antibiotics should be prescrltjed with caution in individuals with a history of gastrointestinal disease, particularly colitis. • Safety and effectiveness have not been determined in pre^ancy, lactation, and infants less than one month oIl'. Ceclof penetrates mother's milk. Exercise caution in prescribing for these patients. Adverse Reacttos: (percentage of patients) Therapy-related adverse reactions are uncommon. Those reported include: • Hypersensitivity reactions have been reported in about 1,5% of patients and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur in less than 1 in 2(W patiems. Cases of semm-sickmss-Jfke reactions have been r^orted with the use of Ceclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied l)y arthritis/arthralgia, wltti or without fever, and differ from classic serum sickness in that there fs Infrequemfy associated lyn^)haden(^thy and proteinuria, no circulating immune complexes, and no evidence to date o1 sequelae of the reaction. While further investigation is ongoing, serum^ickfless-iHte reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with Ceclor. Such reactlMis have been reported more frequemiy in children than In adults with an overall occurrence ranging from 1 in 200 (0.5%) in one focused trial to 2 In 8,346 (0.024%) in overall clinical trials (with an incidence in children In dintcal trials of 0.055%) to 1 in 38.000 (O.CS)3%) in spontaneous event reports. Signs and symptoms usually occur a few days after Initiation of th^y and subside within a few days after cessation of thefi)y; occasionally these reactions have resulted In hospitalization, usually of short duration {m&im hospitalization=two to three days, based on postmarketing surveillance studies). In those requirlr^ hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of die severe reactions occurring in children. Amihistamlnes and glucocorticoids appear to enhance resolution of the signs and symptoms, fto serious sequelae have been reported. • Stevens-Johnson syndrome, toxic epkJermal necrolysis, and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patients with a history of penicillin allergy. • Gastrointestinal {mostly dlarriiea): 2.5% • Symptoms of pseudomembranous collds may appear either during or after amiblotic treatrnem. • As with some penicillins and some other cephalosporins. transient h^titls and cholestatto iaufflfice have been reported rarely. • Rare^, reversible h^je«ctlvlty. nervousness, Insomnia, confusion, hypertonia, dizziness, and sornnolence have been report^. «Other: eoslnophilla, 2%; genital pruritus or va^is, less than 1% ami. rarely, thrombocyt{K)enla and reversible interstitial nephritis. A^rmaljties in latwratory results of uncertain etiology. • Slight elevations in h^atlc enzymes. • Transient lymphocytosis, leukopenia, and. rarely, hemolytic anemia and reversible neutrop^. • Rare rep^s of Increased prothromtHn time with or without clinical bleeding In patients receding Ceclor and Coumadin concomltamiy. • Abnormal urinalysis; elevations In BUN or serum creatinine. • Positive direct Coomtjs' test. • False-positive tests for urinary glucose with Benedicts or Fehllng's solution and Climtest® tablets but not with Tes-Tape* (glucose enzymatic test strip. Lilly). PA 8791 AMP [021490lfil] Additional information available to the profession on request from Bfl Lilly and Conniany, lndlanap(Mis, Indiana 46285. QiU»yMstri0s,lnc Carolina, Puerto Rico IX)630 A Subsidiary of Bl Ullyand Indianapolis, Indiana CR-0525-B-049333 © 1990, EU UaV ANO COMPANY
Object Description
Rating | |
Fixed Title * | NCHH-17: North Carolina Medical Journal [1940-Present] |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1990 |
Identifier | NCHH-17-051 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 51 |
Health Discipline | Medicine |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-051.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-051 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Description
Fixed Title * | Page 588 (advert) |
Document Title | North Carolina Medical Journal [1940-Present] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1990 |
Identifier | NCHH-17-051-0968 |
Form General | Periodicals |
Page Type | all; all images; advertisement |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | ncmed511990medi_0968.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 51 |
Issue Number | 11 |
Page Number | 588 |
Health Discipline | Medicine |
Full Text | ^ imoke-.there may be bronchitis "Recent research has delineated early, more subtle changes in lung and -Immune functions. These alterations directly predispose smokers to respiratory tract infection." Am fam Phys 1987;36:133-140 Established therapy for today's patients For respiratory tract Infections due to susceptible strains of Indicated organisms Brfef Sufflmary. Consult tl» package IftBratore for prescffiitag WormatkM. IfidlGatlon: Lower respifatory infectiofls. Including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes (group A 3-tiemolytlc streptococci). Ccmtralmticathffl: Known allergy to cephalosporins. Warnings: CECLOR SHOULD BE ADMINISTERED CAUTIOUSLY TO PENICILLIN-SENSITIVE PATIENTS. PENICILLINS AND CEPHALOSPORINS SHCRS PARTIAL CROSS-ALLEfiGENICITY. POSSIBLE REACTIONS INCLUDE ANAPHYLAXIS. Administer cautiously to altefgic patients. Pseudomemtjranous colitis has been reported with virtually all tjroad-spectrum antibiotics. It must be considered in differential diagnosis of antibiotic-associated diarrhea. Colon flora is altered by broad-spectrum antibiotic treatment, possibly resulting in antibiotic-associated colitis. Pracautions; • Discontinue Ceclor In the event of aliergN: reactions to it. • Prolonged use may result in overgrowth of non-susceptible organisms. • Positive direct Coombs' tests have been reported during treatment with cephalosporins. • Oeclor should be administered with caution in ttie presence of markedly impaired renal hjnction. Although dosage adjustments in moderate to severe renal Impairment are usually not required, careful clinical ob^rvatlon and laboratory studies should be made. • Sroad-spBGtrum antibiotics should be prescrltjed with caution in individuals with a history of gastrointestinal disease, particularly colitis. • Safety and effectiveness have not been determined in pre^ancy, lactation, and infants less than one month oIl'. Ceclof penetrates mother's milk. Exercise caution in prescribing for these patients. Adverse Reacttos: (percentage of patients) Therapy-related adverse reactions are uncommon. Those reported include: • Hypersensitivity reactions have been reported in about 1,5% of patients and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur in less than 1 in 2(W patiems. Cases of semm-sickmss-Jfke reactions have been r^orted with the use of Ceclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied l)y arthritis/arthralgia, wltti or without fever, and differ from classic serum sickness in that there fs Infrequemfy associated lyn^)haden(^thy and proteinuria, no circulating immune complexes, and no evidence to date o1 sequelae of the reaction. While further investigation is ongoing, serum^ickfless-iHte reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with Ceclor. Such reactlMis have been reported more frequemiy in children than In adults with an overall occurrence ranging from 1 in 200 (0.5%) in one focused trial to 2 In 8,346 (0.024%) in overall clinical trials (with an incidence in children In dintcal trials of 0.055%) to 1 in 38.000 (O.CS)3%) in spontaneous event reports. Signs and symptoms usually occur a few days after Initiation of th^y and subside within a few days after cessation of thefi)y; occasionally these reactions have resulted In hospitalization, usually of short duration {m&im hospitalization=two to three days, based on postmarketing surveillance studies). In those requirlr^ hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of die severe reactions occurring in children. Amihistamlnes and glucocorticoids appear to enhance resolution of the signs and symptoms, fto serious sequelae have been reported. • Stevens-Johnson syndrome, toxic epkJermal necrolysis, and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patients with a history of penicillin allergy. • Gastrointestinal {mostly dlarriiea): 2.5% • Symptoms of pseudomembranous collds may appear either during or after amiblotic treatrnem. • As with some penicillins and some other cephalosporins. transient h^titls and cholestatto iaufflfice have been reported rarely. • Rare^, reversible h^je«ctlvlty. nervousness, Insomnia, confusion, hypertonia, dizziness, and sornnolence have been report^. «Other: eoslnophilla, 2%; genital pruritus or va^is, less than 1% ami. rarely, thrombocyt{K)enla and reversible interstitial nephritis. A^rmaljties in latwratory results of uncertain etiology. • Slight elevations in h^atlc enzymes. • Transient lymphocytosis, leukopenia, and. rarely, hemolytic anemia and reversible neutrop^. • Rare rep^s of Increased prothromtHn time with or without clinical bleeding In patients receding Ceclor and Coumadin concomltamiy. • Abnormal urinalysis; elevations In BUN or serum creatinine. • Positive direct Coomtjs' test. • False-positive tests for urinary glucose with Benedicts or Fehllng's solution and Climtest® tablets but not with Tes-Tape* (glucose enzymatic test strip. Lilly). PA 8791 AMP [021490lfil] Additional information available to the profession on request from Bfl Lilly and Conniany, lndlanap(Mis, Indiana 46285. QiU»yMstri0s,lnc Carolina, Puerto Rico IX)630 A Subsidiary of Bl Ullyand Indianapolis, Indiana CR-0525-B-049333 © 1990, EU UaV ANO COMPANY |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-051.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-051 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
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