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2 NORTH CAROLINA MEDICAL JOURNAL April, 1940 i two doses of ire given at ' the tetar- w blood ' 7? & each of tetanus toxoid hree month intervals, concentration in the a point not quite suffi-from the disease; but — a cc. of tetanus toxoid is given the tetanus antitoxin in the blood will immediately increase and rise to a higher level than when 1500 units of tetanus antitoxin is given and this level is sustained in the blood stream longer than when tetanus antitoxin is given. A routine which is practical would be to give 1 cc. of tetanus toxoid at the same time that diphtheria toxoid is given. Give 2 doses at two month intervals. Later, if the child gets an injury, a third dose of tetanus toxoid may be given instead of tetanus antitoxin. The dangers of horse serum reactions are thereby eliminated. A measure which I have routinely adopted is to give all patients with eczema, hayfever and asthma two injections of tetanus toxoid at two or three month intervals. If they get a rusty nail puncture later, they are given the third dose of tetanus toxoid, 1 cc., and no antitoxin is given. Whooping Cough I know that all of you who have done much general practice have given whooping cough vaccine. I have probably given a barrel of the vaccine originally put out by our State Board of Health. I do not believe it benefited 10 per cent, if any of the cases. It was often given for the lack of something better to do, when doing nothing would have been better practice. Sauer’s whooping cough vaccine is of definite value as a prophylactic remedy, but not as a therapeutic remedy. Dr. Sauer advises that it should be given three to four months before exposure if beneficial results are to be expected. In the past four years I have given 290 infants and children Sauer’s whooping cough vaccine as a routine prophylactic measure. Of this number seven cases developed pertussis either while being treated or within two weeks after treatment was finished. Two children developed light cases three years later. In one family of four children, ages four, three, two years, and five weeks, the oldest child was treated at ten months with Sauer’s whooping cough vaccine. One month ago the three and two year old sisters developed very definite cases of whooping cough with all the typical signs, cough and whooping, and vomiting. The older child escaped. The five weeks old infant was given hyperimmune serum after being exposed to his sisters for ten days. Three doses of 10 cc. each were given three days apart. He was beginning to cough when the serum was started. At the end of one week he had stopped coughing and escaped completely. Another four weeks old baby was exposed in his own home to his sister and aunt who had whooping cough. He had been coughing for one week when serum was given, and two doses of 10 cc. of hyperimmune serum at three day intervals satisfactorily aborted his case. A third patient, who had had severe pertussis for three weeks, was given four doses of 12, 20, 30, and 20 cc. at three day intervals. He was very little improved at the end of four weeks. Because of his anemia he was given two transfusions which could well have explained the slight improvement he made. At the end of four weeks he still had bad and rather frequent paroxysms. This case showed a blood count on admission on February 25, 1939, of Hgb. 65 per cent, RBC 4,000,000, WBC 57,850, Polys 76, Lymphs 22, Monos 2. On March 4 the blood examination after two transfusions showed: Hgb. 100 per cent, RBC 5,200,000, WBC 29,000, Polys 47, Lymphs 50, Monos 2, Eosinophils 1. A fourth case was an infant of three months who had had whooping cough for two weeks when the hyperimmune whooping cough serum was given. She received three doses of 10 cc. each at two day intervals. Her blood examination on admission showed : Hgb. 60 per cent, WBC 31,030, RBC 3,375,- 000, Polys 16, Lymphs 84. Because of her anemia she was given two small transfusions on successive days in conjunction with the hyperimmune serum. Her last dose of hyperimmune serum was given at the end of the third week. Her blood examination following the transfusions and serum showed: Hgb. 85 per cent, RBC 4,150,000, WBC 25,-860, Polys 20, Lymphs 80. A very definite but not spectacular response to the serum was obtained in her case. In three of these four cases a definite response was obtained. Those receiving the
Object Description
Rating | |
Fixed Title * | NCHH-17: North Carolina Medical Journal [1940-2001] |
Document Title | North Carolina Medical Journal [1940-2001] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1940 |
Identifier | NCHH-17-001 |
Form General | Periodicals |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 1 |
Health Discipline | Medicine |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-001.pdf |
Document Sort | all; nchh-17 |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-001 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
Description
Fixed Title * | Page 206 |
Document Title | North Carolina Medical Journal [1940-2001] |
Subject Topical Other | Public Health -- Periodicals.; Physicians -- North Carolina -- Directory.; Societies, Medical -- North Carolina -- Periodicals. |
Description | Includes Transactions of the Society, -1960; 1961- , Transactions issued separately, bound in.; Includes Transactions of the auxiliary to the Medical Society of the State of North Carolina and Proceedings of the North Carolina Public Health Association. Official organ of the Medical Society of the State of North Carolina, 1940-May 1972; of the North Carolina Medical Society, June 1972-. Vols. for 1940-May 1972 published by the Medical Society of the State of North Carolina; June 1972- by the North Carolina Medical Society. |
Contributor | Medical Society of the State of North Carolina. Transactions.; Medical Society of the State of North Carolina.; North Carolina Medical Society.; North Carolina Medical Society. Transactions.; North Carolina Public Health Association. Proceedings. |
Publisher | [Winston-Salem] : North Carolina Medical Society [etc.], 1940- |
Repository | University of North Carolina at Chapel Hill. Health Sciences Library. |
Host | University of North Carolina at Chapel Hill |
Date | 1940 |
Identifier | NCHH-17-001-0224 |
Form General | Periodicals |
Page Type | all; article |
Language | English |
Rights | This item is part of the North Carolina History of Health Digital Collection. Some materials in the Collection are protected by U.S. copyright law. This item is presented by the Health Sciences Library of the University of North Carolina at Chapel Hill for research and educational purposes. It may not be republished or distributed without permission of the Health Sciences Library. |
Filename | northcarolinamed11940medi_0224.jp2 |
Digital Collection | North Carolina History of Health Digital Collection |
Sponsor | The North Carolina History of Health Digital Collection is an open access publishing initiative of the Health Sciences Library of the University of North Carolina at Chapel Hill. Financial support for the initiative was provided in part by a multi-year NC ECHO (Exploring Cultural Heritage Online) digitization grant, awarded by the State Library of North Carolina, and funded through the Library Services and Technology Act (LSTA). |
Volume Number | 1 |
Issue Number | 4 |
Page Number | 206 |
Health Discipline | Medicine |
Full Text | 2 NORTH CAROLINA MEDICAL JOURNAL April, 1940 i two doses of ire given at ' the tetar- w blood ' 7? & each of tetanus toxoid hree month intervals, concentration in the a point not quite suffi-from the disease; but — a cc. of tetanus toxoid is given the tetanus antitoxin in the blood will immediately increase and rise to a higher level than when 1500 units of tetanus antitoxin is given and this level is sustained in the blood stream longer than when tetanus antitoxin is given. A routine which is practical would be to give 1 cc. of tetanus toxoid at the same time that diphtheria toxoid is given. Give 2 doses at two month intervals. Later, if the child gets an injury, a third dose of tetanus toxoid may be given instead of tetanus antitoxin. The dangers of horse serum reactions are thereby eliminated. A measure which I have routinely adopted is to give all patients with eczema, hayfever and asthma two injections of tetanus toxoid at two or three month intervals. If they get a rusty nail puncture later, they are given the third dose of tetanus toxoid, 1 cc., and no antitoxin is given. Whooping Cough I know that all of you who have done much general practice have given whooping cough vaccine. I have probably given a barrel of the vaccine originally put out by our State Board of Health. I do not believe it benefited 10 per cent, if any of the cases. It was often given for the lack of something better to do, when doing nothing would have been better practice. Sauer’s whooping cough vaccine is of definite value as a prophylactic remedy, but not as a therapeutic remedy. Dr. Sauer advises that it should be given three to four months before exposure if beneficial results are to be expected. In the past four years I have given 290 infants and children Sauer’s whooping cough vaccine as a routine prophylactic measure. Of this number seven cases developed pertussis either while being treated or within two weeks after treatment was finished. Two children developed light cases three years later. In one family of four children, ages four, three, two years, and five weeks, the oldest child was treated at ten months with Sauer’s whooping cough vaccine. One month ago the three and two year old sisters developed very definite cases of whooping cough with all the typical signs, cough and whooping, and vomiting. The older child escaped. The five weeks old infant was given hyperimmune serum after being exposed to his sisters for ten days. Three doses of 10 cc. each were given three days apart. He was beginning to cough when the serum was started. At the end of one week he had stopped coughing and escaped completely. Another four weeks old baby was exposed in his own home to his sister and aunt who had whooping cough. He had been coughing for one week when serum was given, and two doses of 10 cc. of hyperimmune serum at three day intervals satisfactorily aborted his case. A third patient, who had had severe pertussis for three weeks, was given four doses of 12, 20, 30, and 20 cc. at three day intervals. He was very little improved at the end of four weeks. Because of his anemia he was given two transfusions which could well have explained the slight improvement he made. At the end of four weeks he still had bad and rather frequent paroxysms. This case showed a blood count on admission on February 25, 1939, of Hgb. 65 per cent, RBC 4,000,000, WBC 57,850, Polys 76, Lymphs 22, Monos 2. On March 4 the blood examination after two transfusions showed: Hgb. 100 per cent, RBC 5,200,000, WBC 29,000, Polys 47, Lymphs 50, Monos 2, Eosinophils 1. A fourth case was an infant of three months who had had whooping cough for two weeks when the hyperimmune whooping cough serum was given. She received three doses of 10 cc. each at two day intervals. Her blood examination on admission showed : Hgb. 60 per cent, WBC 31,030, RBC 3,375,- 000, Polys 16, Lymphs 84. Because of her anemia she was given two small transfusions on successive days in conjunction with the hyperimmune serum. Her last dose of hyperimmune serum was given at the end of the third week. Her blood examination following the transfusions and serum showed: Hgb. 85 per cent, RBC 4,150,000, WBC 25,-860, Polys 20, Lymphs 80. A very definite but not spectacular response to the serum was obtained in her case. In three of these four cases a definite response was obtained. Those receiving the |
Digital Format | JPEG 2000 |
Print / Download PDF Version | http://archives.hsl.unc.edu/nchh/nchh-17/nchh-17-001.pdf |
Document Sort | all; nchh-17 |
Article Title | Prophylactic Measures Of Proven Value In Some Of The Infectious Diseases |
Article Author | J Buren Sidbury |
Volume Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/identi/searchterm/NCHH-17-001 |
Title Link | http://dc.lib.unc.edu/cdm/search/collection/nchh/field/documa/searchterm/NCHH-17 |
Catalog Record link | http://search.lib.unc.edu/search?R=UNCb1306322 |
Revision History | done |
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